The Immun4Cure cohort constitutes an extensive clinical and biological platform dedicated to the study of autoimmune diseases across both adult and pediatric populations.
Through this cohort, scientists and clinicians aim to unravel the complex mechanisms of immune dysregulation and identify new biomarkers and therapeutic targets that can ultimately improve patient care.
Each participant undergoes comprehensive clinical follow-up and biological sampling, generating a rich dataset that integrates clinical, biological, imaging, and environmental information.
The program brings together more than 40 clinical and research teams across multiple specialties – including rheumatology, immunology, pneumology, nephrology, hematology, internal medicine, pediatrics, dermatology, virology, gynecology, oncology, and imaging – creating a multidisciplinary research ecosystem.
Autoimmune and dysimmune diseases have multifactorial origins, involving genetic susceptibility, environmental exposures, and immune dysregulation.
While major therapeutic advances have been achieved with immunomodulatory drugs and biologics, patients still experience relapse, treatment resistance, or unpredictable disease progression. The Immun4Cure cohort addresses these challenges by combining deep immune phenotyping, multi-omics analyses, and long-term large clinical data, paving the way toward personalized immunotherapy.
The cohort is organized into several major participant groups, reflecting the diversity of autoimmune presentations:
The cohort’s biobank serves as a cornerstone of Immun4Cure.
The Biological Resource Center (CRB) of Montpellier University Hospital is a key component of this infrastructure, ensuring the collection, qualification, and long-term preservation of human biological resources.
The CRB collects and stores a wide range of biological materials — including blood, serum, saliva, stool, DNA/RNA, and disease-specific tissues such as synovial biopsies or skin samples.
The CRB benefits from a centralized, high-throughput, and fully automated analytical and storage chains. Certified ISO 20387, it bridges clinical care and research, with a major innovation being the interoperability between the hospital’s automated pre-analytical line and CRB storage systems.
Imaging data and deep phenotyping enrich the dataset, while lifestyle, treatment, and environmental information are recorded. All data are securely stored within a dedicated Immun4Cure digital platform, connected to national health databases.
The Immun4Cure cohort supports translational research at multiple levels:
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